Many points of fire ignition are aggregated at the vicinity of roads in French Mediterranean Provence area. High car traffic and public attendance entail high fire hazard on neighbouring forests and wildland areas. Fire mitigation strategies at these interfaces may include the management of herbaceous and shrubby vegetation, and the spatial organization of vegetation facies. As such techniques are costly and the cumulated interface length is very high, managers are interested in optimised strategies. In a previous study (Curt & Delcros, 2009) we built a cellular automaton to simulate fire ignition and initial propagation in road-forest interfaces, using data from experimental burnings. This model was used to assess the relative importance of vegetation type, fuel treatment and spatial patterning of vegetation on the fire hazard. In this study, we used statistical optimisation techniques to minimize fire hazard for different (real and theoretical) interface sceneries. Results indicate that managing about 20% of the area can strongly reduce fire hazard in interfaces dominated by highly flammable vegetation. As the location of the initial point of ignition affects strongly fire ignition and propagation, it is recommended to manage intensively areas located at the immediate vicinity of roads, and areas submitted to high public attendance. Optimization techniques seem efficient to help building firewise management practices at road-forest interfaces.